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Merck
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Documenti fondamentali

810180P

Avanti

TopFluor™ TMR PC

Avanti Research™ - A Croda Brand

Sinonimo/i:

1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine

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About This Item

Formula empirica (notazione di Hill):
C53H82 BF2N4 O10P
Peso molecolare:
1015.02
Codice UNSPSC:
12352211
NACRES:
NA.25

Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 1 mg (810180P-1mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

Tetramethylrhodamine (TMR) phosphatidylcholine (PC) is a fatty acid labeled fluorescent phospholipid. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotes. It is the prime metabolite of glycerolipid metabolism.

Applicazioni

TopFluor™ TMR PC or 1-oleoyl-2-(6-((4,4-difluoro-1,3-dimethyl-5-(4-methoxyphenyl)-4-bora-3α,4α-diaza-s-indacene-2-propionyl)amino)hexanoyl)-sn-glycero-3-phosphocholine may be used for the formation of lipid membranes in microarrays.

Azioni biochim/fisiol

TopFluor™-labeled lipids have spectral properties similar to tetramethylrhodamine (TMR).

Confezionamento

5 mL Amber Glass Screw Cap Vial (810180P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available

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Rikiya Watanabe
Biochimica et biophysica acta. General subjects, 1864(2), 129330-129330 (2019-03-31)
Micro-chamber arrays enable highly sensitive and quantitative bioassays at the single-molecule level. Accordingly, they are widely used for ultra-sensitive biomedical applications, e.g., digital PCR and digital ELISA. However, the versatility of micro-chambers is generally limited to reactions in aqueous solutions
Single-molecule analysis of phospholipid scrambling by TMEM16F
Rikiya W, et al.
Proceedings of the National Academy of Sciences of the USA, 115(12), 3066-3071 (2018)
Rikiya Watanabe et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(12), 3066-3071 (2018-03-07)
Transmembrane protein 16F (TMEM16F) is a Ca2+-dependent phospholipid scramblase that translocates phospholipids bidirectionally between the leaflets of the plasma membrane. Phospholipid scrambling of TMEM16F causes exposure of phosphatidylserine in activated platelets to induce blood clotting and in differentiated osteoblasts to
Libing Mu et al.
Nature communications, 9(1), 4259-4259 (2018-10-17)
Phagocytosis is one of the earliest cellular functions, developing approximately 2 billion years ago. Although FcR-based phagocytic signaling is well-studied, how it originated from ancient phagocytosis is unknown. Lipid redistribution upregulates a phagocytic program recapitulating FcR-based phagocytosis with complete dependence

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