700140P

6-keto-5α-hydroxycholesterol

Avanti Research^™ - A Croda Brand 700140P, powder

• Sinonimo/i: 3β,5α-dihydroxy-cholestan-6-one
• Formula empirica (notazione di Hill): C₂₇H₄₆O₃
• Numero CAS: 13027-33-3
• Peso molecolare: 418.65
• Numero MDL: MFCD00271438
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 5 mg (700140P-5mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand 700140P
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: O[C@]21[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)CC2=O)(CC[C@@H](C1)O)C
• InChI: 1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1; SJZZRXMQSAXCFD-ZCBMJONGSA-N

Descrizione

Descrizione generale

6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol.

Azioni biochim/fisiol

6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes.

Confezionamento

5 mL Amber Glass Screw Cap Vial (700140P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids