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Documenti fondamentali

700138P

Avanti

7-dehydrodesmosterol

powder

Sinonimo/i:

Cholesta-5,7,24-trien-3β-ol

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About This Item

Formula empirica (notazione di Hill):
C27H42O
Numero CAS:
1715-86-2
Peso molecolare:
382.62
Numero MDL:
MFCD28359052
Codice UNSPSC:
12352211
NACRES:
NA.25

Stato

powder

Confezionamento

pkg of 1 × 1 mg (700138P-1mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 700138P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Stringa SMILE

O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCC=C(C)C)C)C3=CC=C2C1)C)C

InChI

1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1
RUSSPKPUXDSHNC-DDPQNLDTSA-N

Descrizione generale

7-dehydrodesmosterol (7-DHD) is synthesized via the Bloch pathway. 7-DHD serves as a desmosterol synthesis precursor and the enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes this step.

Applicazioni

7-dehydrodesmosterol has been used as an internal oxysterol standard in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS).

Azioni biochim/fisiol

7-dehydrodesmosterol (7-DHD) levels are higher during fetal development and increases with aging. Elevated levels of 7-DHD is associated with Smith-Lemli-Opitz syndrome mouse model. Reduced levels of 7-DHD is observed in shiverer and quaking disorder.

Confezionamento

5 mL Amber Glass Screw Cap Vial (700138P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

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Colesta-3,5-diene ≥93% (HPLC)

Sigma-Aldrich

C6012

Colesta-3,5-diene

7-Dehydrocholesterol ≥95.0% (HPLC)

Sigma-Aldrich

30800

7-Dehydrocholesterol

J M Bourre et al.
Journal of neurochemistry, 54(4), 1196-1199 (1990-04-01)
In rat sciatic nerve, the 7-dehydrocholesterol content decreased dramatically during the postnatal period and slowly during adulthood and aging. In contrast, the 7-dehydrodesmosterol content peaked at 14 days and was nearly undetectable after 60 days. The desmosterol content peaked at
Josi Herron et al.
Current protocols in toxicology, 78(1), e65-e65 (2018-10-16)
Cholesterol and cholesterol-derived oxysterols are critical for embryonic development, synapse formation and function, and myelination, among other biological functions. Indeed, alterations in levels of cholesterol, sterol precursors, and oxysterols result in a variety of developmental disorders, emphasizing the importance of
Vladimiro Cardenia et al.
Biochimie, 153, 99-108 (2018-08-06)
The electronic cigarettes (e-cigarettes, e-cigs) have become the most sought-after alternative to the traditional cigarettes, partly due to the widespread perception of safety. However, the high temperature reached by e-cig solutions can generate toxic compounds, some of which are listed

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