700047P

5α,6α-epoxycholestanol-d7

Avanti Research^™ - A Croda Brand

• Sinonimo/i: cholestanol, 5α,6α-epoxy-d7
• Formula empirica (notazione di Hill): C₂₇H₃₉O₂D₇
• Numero CAS: 127685-38-5
• Peso molecolare: 409.70
• Numero MDL: MFCD00057815
• Codice UNSPSC: 12352100
• NACRES: NA.25

Proprietà

• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 1 mg (700047P-1mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation. 5α,6α-epoxycholestanol-d7 is a deuterated derivative of 5α,6α-EC. It is catabolized by the enzyme cholesterol-5,6-epoxide hydrolase (ChEH) enzyme to 3β,5α,6β-triol.

Applicazioni

5α,6α-epoxycholestanol-d7 has been used as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondrial samples. It may be used as an internal standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis of plasma samples.

Azioni biochim/fisiol

5α,6α-epoxycholestanol (5α,6α-EC) is a liver X receptor (LXR) antagonist. 5α,6α-EC is employed in anticancer treatments. It impairs redox state and affects atherogenesis. The levels of 5α,6α-EC are elevated in hypercholesterolemia. It mediates steroid receptor coactivator (SRC) recruitment.

Confezionamento

5 mL Amber Glass Screw Cap Vial (700047P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids