D152609
2,2-Dimethylbutyric acid
96%
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About This Item
Prodotti consigliati
Livello qualitativo
Saggio
96%
Forma fisica
liquid
Indice di rifrazione
n20/D 1.4154 (lit.)
P. eboll.
94-96 °C/5 mmHg (lit.)
Densità
0.928 g/mL at 25 °C (lit.)
Stringa SMILE
CCC(C)(C)C(O)=O
InChI
1S/C6H12O2/c1-4-6(2,3)5(7)8/h4H2,1-3H3,(H,7,8)
VUAXHMVRKOTJKP-UHFFFAOYSA-N
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
174.2 °F - closed cup
Punto d’infiammabilità (°C)
79 °C - closed cup
Dispositivi di protezione individuale
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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ST-20 (sodium 2,2-dimethylbutyrate) is a potential therapeutic agent for treatment of β-thalassemia and sickle cell disease. A subchronic oral toxicity study was conducted in Sprague-Dawley rats (10/sex/dose) at gavage dosages of 0 (vehicle control), 200, 600, or 1,000 mg/kg, once
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American journal of hematology, 87(11), 1017-1021 (2012-08-14)
Therapeutics which reduce the pathology in sickle cell syndromes are needed, particularly noncytotoxic therapeutics. Fetal hemoglobin (HbF, α(2) γ(2) ) is established as a major regulator of disease severity; increased HbF levels correlate with milder clinical courses and improved survival.
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