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Documenti

B38503

Sigma-Aldrich

Bis(2-chloroethyl)amine hydrochloride

98%

Sinonimo/i:

β,β′-Dichlorodiethylamine hydrochloride, 1,5-Dichloro-3-azapentane hydrochloride, 2,2′-Dichlorodiethylamine hydrochloride, 2-Chloro-N-(2-chloroethyl)ethanamine hydrochloride, Bi(2-chloroethyl)amine hydrochloride, Bis(β-chloroethyl)amine hydrochloride, Bis(2-chloroethyl)ammonium chloride, Di(2-chloroethyl)amine hydrochloride, N,N-Bis(2-chloroethyl)amine hydrochloride, Nornitrogen mustard hydrochloride

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About This Item

Formula condensata:
(ClCH2CH2)2NH·HCl
Numero CAS:
821-48-7
Peso molecolare:
178.49
Beilstein:
3550356
Numero CE:
212-479-5
Numero MDL:
MFCD00012515
Codice UNSPSC:
12352100
ID PubChem:
24891737
NACRES:
NA.22

Saggio

98%

Forma fisica

powder

Punto di fusione

212-214 °C (lit.)

Stringa SMILE

Cl.ClCCNCCCl

InChI

1S/C4H9Cl2N.ClH/c5-1-3-7-4-2-6;/h7H,1-4H2;1H
YMDZDFSUDFLGMX-UHFFFAOYSA-N

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Descrizione generale

Bis(2-chloroethyl)amine hydrochloride is used as a starting material to synthesize piperazine derivatives.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H290,H302,H314

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

No information available.

Punto d’infiammabilità (°C)

No information available.

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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B Hartley-Asp
The Prostate, 5(1), 93-100 (1984-01-01)
In growth proliferation experiments on two human prostatic carcinoma cell lines, DU 145 cells were found to be more sensitive to the cytotoxic effect of estramustine and nor-nitrogen mustard than PC-3 cells. Estramustine was, however, much more cytotoxic in both
E Kruse et al.
Pharmacology & toxicology, 64(1), 9-13 (1989-01-01)
To further clarify the mode of action of estramustine, the influence on macromolecular synthesis in the human prostatic tumour cell line 1013L was investigated. Cell treatment with estramustine, nor-nitrogen mustard and tauromustine, followed by radioactive nucleotide and leucine incorporations, as
G Momerency et al.
Biological mass spectrometry, 23(3), 149-158 (1994-03-01)
A method is described for the determination of the antitumour drug cyclophosphamide and six stable metabolites in plasma of cancer patients, namely dechloroethyl-cyclophosphamide, 4-keto-cyclophosphamide, carboxy-phosphamide, alcophosphamide, nor-nitrogen mustard and the N-chloroethyl-1,3-oxazolidine-2-one, as methyl and/or trifluoroacetyl derivatives by single ion monitoring
B Hartley-Asp et al.
The Journal of urology, 127(4), 818-822 (1982-04-01)
Estramustine at concentrations ranging from 3-40 x 10(-6) M inhibited the cell growth and clonogenic survival of a human prostatic carcinoma cell line (DU 145). This cell line was found to be unresponsive to estradiol and testosterone at concentrations ranging
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