936553

(S,R,S)-AHPC-acetamido-O-PEG4-C1-acid

≥95%

• Sinonimo/i: (S,R,S)-AHPC-acetamido-O-PEG4-C1-acid, (S)-19-[[(2S,4R)-4-Hydroxy-2-[[4-(4-methylthiazol-5-yl)benzyl]carbamoyl]pyrrolidin-1-yl]carbonyl]-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoic acid, L-Prolinamide, N-(16-carboxy-1-oxo-3,6,9,12,15-pentaoxahexadec-1-yl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
• Formula empirica (notazione di Hill): C₃₄H₅₀N₄O₁₁S
• Numero CAS: 2172820-13-0
• Peso molecolare: 722.85
• Numero MDL: MFCD33020897
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• ligand: VH032
• Livello qualitativo: 100
• Saggio: ≥95%
• Forma fisica: solid (or Chunk(s))
• Colore: off-white to light yellow
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C([C@@H](NC(COCCOCCOCCOCCOCC(O)=O)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1

Descrizione

Applicazioni

(S,R,S)-AHPC-acetamido-O-PEG4-C1-acid is a functionalized von Hippel-Lindau (VHL) ligand. It contains a terminal carboxyl group for conjugation with amine linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks

Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable