934291

Thalidomide-O-amido-C₈-NH₂ trifluoroacetate

≥95.0%

• Sinonimo/i: N-(8-Aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide trifluoroacetate
• Formula empirica (notazione di Hill): C₂₃H₃₀N₄O₆·C₂HF₃O₂
• Numero CAS: 1950635-16-1
• Peso molecolare: 572.53
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• ligand: thalidomide
• Livello qualitativo: 100
• Saggio: ≥95.0%
• Forma fisica: powder or crystals
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(C(F)(F)F)[O-].O=C(COC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O)NCCCCCCCC[NH3+]

Descrizione

Applicazioni

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Note legali

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H312,H360D
• Consigli di prudenza: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Classi di pericolo: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable