934283

4-(Aminoethyl)-1-N-Boc-piperidine

≥95.0%

• Sinonimo/i: 1-tert-Butoxycarbonyl-4-piperidineethanamine, 2-(N-tert-Butoxycarbonyl-4-piperidinyl)ethylamine
• Formula empirica (notazione di Hill): C₁₂H₂₄N₂O₂
• Numero CAS: 146093-46-1
• Peso molecolare: 228.33
• Numero MDL: MFCD04038459
• Codice UNSPSC: 12352200
• NACRES: NA.21

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95.0%
• Stato: semisolid
• Colore: off-white to light yellow
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(OC(C)(C)C)N1CCC(CCN)CC1

Descrizione

Applicazioni

A semi-flexible linker useful for PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of PROTACs may impact degradation kinetics as well as drug design (absorption; distribution; metabolism; excretion; and toxicity; ADMET) properties of PROTACs.

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Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Note legali

PROTAC^® is a registered trademark of Arvinas Operations; Inc.; and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable