930636

VH 032 amide-alkyl C₅-acid

≥95%

• Sinonimo/i: (S,R,S)-AHPC-CO-C₅-acid, (S,R,S)-AHPC-amido-C₅-acid, 6-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}hexanoic acid, L-Prolinamide, N-(6-carboxy-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl],methyl]-, (4R)-
• Formula empirica (notazione di Hill): C₂₉H₄₀N₄O₆S
• Numero CAS: 2162120-87-6
• Peso molecolare: 572.72
• Numero MDL: MFCD32903593
• Codice UNSPSC: 12352106
• NACRES: NA.21

Proprietà

• ligand: VH032
• Livello qualitativo: 100
• Saggio: ≥95%
• Stato: powder
• Gruppo funzionale: carboxylic acid
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: C([C@@H](NC(CCCCCC(O)=O)=O)C(C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1
• InChI: 1S/C29H40N4O6S/c1-18-25(40-17-31-18)20-12-10-19(11-13-20)15-30-27(38)22-14-21(34)16-33(22)28(39)26(29(2,3)4)32-23(35)8-6-5-7-9-24(36)37/h10-13,17,21-22,26,34H,5-9,14-16H2,1-4H3,(H,30,38)(H,32,35)(H,36,37)/t21-,22+,26-/m1/s1; LYAMSRXTXVKKIC-TVZXLZGTSA-N

Descrizione

Applicazioni

VH 032 amide-alkyl C₅-acid is a functionalized von-Hippel-Lindau (VHL) ligand with a terminal carboxyl group, allowing rapid conjugation of amine containing linkers. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable