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902659

Sigma-Aldrich

Amino-PEG6-t-butyl ester

Sinonimo/i:

tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H2N-PEG6-CH2CH2COOtBu

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About This Item

Formula empirica (notazione di Hill):
C19H39NO8
Numero CAS:
1286281-32-0
Peso molecolare:
409.51
Numero MDL:
MFCD13184944
Codice UNSPSC:
51171641
NACRES:
NA.22

Stato

liquid

Impiego in reazioni chimiche

reagent type: cross-linking reagent

Indice di rifrazione

n/D 1.4562

Densità

1.06581 g/mL

Gruppo funzionale

amine
ester

Temperatura di conservazione

−20°C

Stringa SMILE

NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

InChI

1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3
QGSFECNPSLZGGT-UHFFFAOYSA-N

Applicazioni

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Prodotti correlati

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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