902586

Hydroxy-PEG4-t-butyl ester

• Sinonimo/i: tert-Butyl-1-hydroxy-3,6,9,12-tetraoxapentadecan-15-oate, HO-PEG4-CO-OtBu
• Formula empirica (notazione di Hill): C₁₅H₃₀O₇
• Numero CAS: 518044-32-1
• Peso molecolare: 322.39
• Codice UNSPSC: 51171641
• NACRES: NA.22

Proprietà

• Saggio: ≥95%
• Forma fisica: liquid
• Impiego in reazioni chimiche: reagent type: cross-linking reagent
• Indice di rifrazione: n/D 1.4492
• Densità: 1.04746 g/mL
• Gruppo funzionale: ester; hydroxyl
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(OC(C)(C)C)CCOCCOCCOCCOCCO
• InChI: 1S/C15H30O7/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h16H,4-13H2,1-3H3; FJRDXEGYAVAMLB-UHFFFAOYSA-N

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Altre note

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Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable