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430471

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

Sinonimo/i:

Lactel® B6006-1, PLGA

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About This Item

Formula condensata:
[C3H4O2]x[C2H2O2]y
Numero MDL:
MFCD00131930
Codice UNSPSC:
12162002
ID PubChem:
24866924
NACRES:
NA.23

Livello qualitativo

100

Forma fisica

amorphous

Rapporto d’alimentazione

lactide:glycolide 85:15

PM

Mw 50,000-75,000

Tempo di degradazione

<6 months

Viscosità

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

Temp. transizione

Tg 45-50 °C

Solubilità

ethyl acetate, chloroform, acetone and THF: soluble

Temperatura di conservazione

2-8°C

Stringa SMILE

OCC(O)=O.CC(O)C(O)=O

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Descrizione generale

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Applicazioni

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Caratteristiche e vantaggi

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Stato fisico

Biocompatible, biodegradable polymer.

Note legali

Lactel is a registered trademark of Evonik Corp

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCH4706
MKCM6080
MKCC2382
MKBT1519V
MKBS9536V

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Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers
Ayelen L Helling et al.
Tissue engineering. Part A, 25(3-4), 214-223 (2018-10-04)
In human skin the junction between the epidermis and dermis undulates. Epidermal stem cells pattern according to their position relative to those undulations. Here we describe a rig in which epidermal cells are cultured on a collagen-coated poly(d,l-lactide-co-glycolide) (PLGA) membrane.
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
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