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Key Documents

409510

Sigma-Aldrich

Poly(ethylene glycol) dimethacrylate

average MN 550, cross-linking reagent polymerization reactions, methacrylate, 80-120 ppm MEHQ as inhibitor, 270-330 ppm BHT as inhibitor

Sinonimo/i:

Polyethylene glycol, PEG dimethacrylate

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About This Item

Formula condensata:
C3H5C(O)(OCH2CH2)nOC(O)C3H5
Numero CAS:
Numero MDL:
Codice UNSPSC:
12162002
ID PubChem:
NACRES:
NA.23

product name

Poly(ethylene glycol) dimethacrylate, average Mn 550, contains 80-120 ppm MEHQ as inhibitor, 270-330 ppm BHT as inhibitor

Forma fisica

liquid

Livello qualitativo

PM

average Mn 550

contiene

270-330 ppm BHT as inhibitor
80-120 ppm MEHQ as inhibitor

Impiego in reazioni chimiche

reagent type: cross-linking reagent
reaction type: Polymerization Reactions

Indice di rifrazione

n20/D 1.466

P. eboll.

>200 °C/2 mmHg (lit.)

Densità

1.099 g/mL at 25 °C

Estremità Ω

methacrylate

Estremità α

methacrylate

Architettura del polimero

shape: linear
functionality: homobifunctional

Temperatura di conservazione

2-8°C

Stringa SMILE

OCCO.CC(=C)C(O)=O

InChI

1S/C10H14O4/c1-7(2)9(11)13-5-6-14-10(12)8(3)4/h1,3,5-6H2,2,4H3
STVZJERGLQHEKB-UHFFFAOYSA-N

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Applicazioni


  • PDGF-AA loaded photo-crosslinked chitosan-based hydrogel for promoting wound healing.: This study investigates the use of a chitosan-based hydrogel, photo-crosslinked with Poly(ethylene glycol) dimethacrylate (PEGDMA), to deliver PDGF-AA and enhance wound healing. The results demonstrate significant improvements in wound closure rates and tissue regeneration (Cai et al., 2024).

  • Reducing the foreign body response on human cochlear implants and their materials in vivo with photografted zwitterionic hydrogel coatings.: This research explores the application of PEGDMA in zwitterionic hydrogel coatings to minimize foreign body responses in cochlear implants. The coatings significantly reduced inflammation and improved biocompatibility in vivo (Horne et al., 2023).

  • Full factorial design of experiment-based and response surface methodology approach for evaluating variation in uniaxial compressive mechanical properties, and biocompatibility of photocurable PEGDMA-based scaffolds.: This study uses a full factorial design to optimize the mechanical properties and biocompatibility of PEGDMA-based scaffolds, highlighting their potential use in tissue engineering and regenerative medicine (Bharadwaz et al., 2023).

  • Antifouling and Mechanical Properties of Photografted Zwitterionic Hydrogel Thin-Film Coatings Depend on the Cross-Link Density.: This article examines how varying the cross-link density in PEGDMA-based hydrogel coatings affects their antifouling and mechanical properties. The findings are relevant for the development of durable and biocompatible medical device coatings (Jensen et al., 2021).

  • Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels.: The research presents the development of PEGDMA/keratin biocomposite hydrogels, demonstrating excellent biocompatibility and potential applications in drug delivery systems and tissue engineering (Wang et al., 2021).

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Laura Ferlauto et al.
Frontiers in neuroscience, 12, 648-648 (2018-10-05)
Reducing the mechanical mismatch between the stiffness of a neural implant and the softness of the neural tissue is still an open challenge in neuroprosthetics. The emergence of conductive hydrogels in the last few years has considerably widened the spectrum
Hailuo Fu et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2245-2250 (2013-03-19)
Implants that simultaneously function as an osteoconductive matrix and as a device for local drug or growth factor delivery could provide an attractive system for bone regeneration. In our previous work, we prepared hollow hydroxyapatite (abbreviated HA) microspheres with a
Pelagie M Favi et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 1935-1944 (2013-03-19)
The culture of multipotent mesenchymal stem cells on natural biopolymers holds great promise for treatments of connective tissue disorders such as osteoarthritis. The safety and performance of such therapies relies on the systematic in vitro evaluation of the developed stem
C Aulin et al.
Laboratory animals, 47(1), 58-65 (2013-03-08)
Articular cartilage has a limited capacity for self-repair in adult humans, and methods used to stimulate regeneration often result in re-growth of fibrous cartilage, which has lower durability. No current treatment option can provide complete repair. The possibility of growth
Cheng Wang et al.
Journal of biomedical nanotechnology, 9(3), 357-366 (2013-04-30)
In this paper, two nanoscale preparations were described for docetaxel encapsulation using poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) (PCEC) copolymer as carrier for treating malignant tumor. The first formulation was docetaxel-loaded PCEC micelle (D-M), which was characterized by XRD, TEM and Malvern laser particle

Articoli

Patterning of PEG-based Hydrogels - Engineering Spatial Complexity

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.