299634
6-(5H)-Phenanthridinone
technical grade
Sinonimo/i:
NSC 11021, NSC 40943, NSC 61083
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About This Item
Formula empirica (notazione di Hill):
C13H9NO
Numero CAS:
Peso molecolare:
195.22
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
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Grado
technical grade
Livello qualitativo
Stato
powder
Punto di fusione
290-292 °C (lit.)
Stringa SMILE
O=C1Nc2ccccc2-c3ccccc13
InChI
1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
RZFVLEJOHSLEFR-UHFFFAOYSA-N
Informazioni sul gene
human ... PARP1(142)
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Categorie correlate
Descrizione generale
6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.
Applicazioni
Reactant involved in:
Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
- Synthesis of 5,6-dihydrophenanthridine sulfonamides
- Oxidative coupling with diphenylacetylene
- Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides
Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:
- Potassium channel KV1.3 and IK-1 inhibitors
- HIV-1 integrase inhibitors
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Alberto Chiarugi et al.
The Journal of pharmacology and experimental therapeutics, 305(3), 943-949 (2003-02-28)
Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and ATP depletion and has been proposed to play a causative role in a
One-pot formation of C-C and C-N bonds through palladium-catalyzed dual C-H activation: synthesis of phenanthridinones.
Guan-Wu Wang et al.
Angewandte Chemie (International ed. in English), 50(6), 1380-1383 (2011-02-04)
J S Ungerstedt et al.
Clinical and experimental immunology, 131(1), 48-52 (2003-01-10)
The present study investigates the modulating effects of nicotinamide on the cytokine response to endotoxin. In an in vitro model of endotoxaemia, human whole blood was stimulated for two hours with endotoxin at 1 ng/ml, achieving high levels of the
Wan-Ju Kim et al.
Toxicology and applied pharmacology, 202(1), 84-98 (2004-12-14)
One of the cellular responses to DNA damaging events is the activation of programmed cell death, also known as apoptosis. Apoptosis is an important process in limiting tumorigenesis by eliminating cells with damaged DNA. This view is reinforced by the
Jonathan Collins et al.
Organic letters, 10(3), 361-364 (2008-01-01)
Solid-state silica-gel-catalyzed opening of aziridine 6 provided phenanthrene 7, whose oxidative cleavage, recyclization, and further elaboration furnished the C-1 aldehyde and carboxylic acid derivatives of 7-deoxypancratistatin for potential analogue synthesis.
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