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282227

Sigma-Aldrich

Chlorhexidine

≥99.5%

Sinonimo/i:

1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]

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About This Item

Formula condensata:
[-(CH2)3NHC(=NH)NHC(=NH)NHC6H4Cl]2
Numero CAS:
55-56-1
Peso molecolare:
505.45
Beilstein:
2826432
Numero CE:
200-238-7
Numero MDL:
MFCD00009673
Codice UNSPSC:
12352100
ID PubChem:
24857031
NACRES:
NA.22

Livello qualitativo

100

Saggio

≥99.5%

Stato

powder

Impurezze

<1.0% water

Punto di fusione

134-136 °C (lit.)

Solubilità

water: soluble 0.08% at 20 °C

Gruppo funzionale

amine
chloro

Stringa SMILE

Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1

InChI

1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)
GHXZTYHSJHQHIJ-UHFFFAOYSA-N

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Descrizione generale

Effect of the chlorhexidine:hydroxypropyl-β-cyclodextrin inclusion compound on in vitro slabs of bovine dentine has been investigated.

Chlorhexidine is a cationic surfactant with broad-spectrum antimicrobial activity. It is used as a disinfectant in periodontal therapy and surgical scrubs.

Applicazioni

Chlorhexidine, the "gold standard" in oral antiseptics, has been used to optimize novel slow release chlorhexidine coatings based on fatty acids in surgical sutures. Chlorhexidine, antibacterial agent, has been used in preparaing chlorhexidine-functionalized calcium phosphate nanoparticles, useful for oral hygiene and dental treatment.

Pittogrammi

CorrosionEnvironment
GHS05,GHS09

Avvertenze

Danger

Indicazioni di pericolo

H318,H410

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
1312398V
1312398
10318BJ
09312PH
10106DH

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vibrant-m

BP068

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vibrant-m

C1520000

Chlorhexidine diacetate

Imidazo[1,2-a]pyridine-7-carboxylic acid AldrichCPR

Sigma-Aldrich

CDS017300

Imidazo[1,2-a]pyridine-7-carboxylic acid

vibrant-m

Y0001545

Chlorhexidine for system suitability

Chlorhexidine acetate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1222

Chlorhexidine acetate

USP

USP

1111103

Chlorhexidine acetate

USP

USP

1443409

Miconazole

Carolina Ferreira Franco et al.
Artificial organs, 27(5), 486-491 (2003-05-20)
The aim of this work was study the effect of the chlorhexidine : hydroxypropyl-beta-cyclodextrin (CLX : HP-beta-CD) inclusion compound (IC) on in vitro slabs of bovine dentine. The substantivity, antimicrobial activity, and morphological effect of this inclusion compound were evaluated.
Chlorhexidine-loaded calcium phosphate nanoparticles for dental maintenance treatment: combination of mineralising and antibacterial effects.
Kovtun A, et al.
Royal Society of Chemistry Advances, 2(3), 870-875 (2012)
Matthias Maiwald et al.
PloS one, 7(9), e44277-e44277 (2012-09-18)
Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis. However, study outcomes due to chlorhexidine-alcohol combinations are often attributed to chlorhexidine alone. Thus, we sought
S Karki et al.
The Journal of hospital infection, 82(2), 71-84 (2012-08-15)
The topical use of chlorhexidine gluconate (CHG) is intended to reduce bacterial density on patients' skin. To assess the impact of body bath or skin cleansing with CHG-impregnated or CHG-saturated washcloths in preventing healthcare-associated infections and colonization. This systematic review
Carolyne Horner et al.
The Journal of antimicrobial chemotherapy, 67(11), 2547-2559 (2012-07-27)
Antiseptic agents are increasingly used for hand hygiene and skin decolonization as key tools for the prevention of healthcare-associated infections. Chlorhexidine, a divalent, cationic biguanide, has a broad spectrum of activity and is one of the most frequently used topical
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