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Documenti

16490

Sigma-Aldrich

Bromopyruvic acid

≥98.0%

Sinonimo/i:

3-Bromo-2-oxopropionic acid

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About This Item

Formula condensata:
BrCH2COCOOH
Numero CAS:
1113-59-3
Peso molecolare:
166.96
Beilstein:
1746786
Numero CE:
214-206-5
Numero MDL:
MFCD00002587
Codice UNSPSC:
12352100
ID PubChem:
57647568
NACRES:
NA.22

Livello qualitativo

200

Saggio

≥98.0%

Forma fisica

(Powder or Crystals or Flakes)

Punto di fusione

77-82 °C

Solubilità

water: soluble 1 g/10 mL, clear to very slightly hazy, colorless

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)C(=O)CBr

InChI

1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)
PRRZDZJYSJLDBS-UHFFFAOYSA-N

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Descrizione generale

Bromopyruvic acid is an affinity label for cysteine residues†. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.
may contain traces of dibromopyruvic acid

Applicazioni

Bromopyruvic acid was used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.

Altre note

Affinity label for cysteine residues; Cross-linker between nucleic acids and proteins

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1B

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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M H Wang et al.
The Biochemical journal, 320 ( Pt 1), 187-192 (1996-11-15)
The kinetic theory of substrate reaction during the modification of enzyme activity [Duggleby (1986) J. Theor. Biol. 123, 67-80; Wang and Tsou (1990) J. Theor. Biol. 142, 531-549] has been applied to a study of the inactivation kinetics of ribonuclease
N Nitta et al.
FEBS letters, 166(1), 194-198 (1984-01-23)
Cytosine in nucleic acids can be converted into N4-aminocytosine by treatment with a mixture of hydrazine and bisulfite. The hydrazino group thus formed at position 4 of the pyrimidine ring can be linked to a sulhydryl group in proteins by
Ananda Herath et al.
Organic letters, 12(3), 412-415 (2009-12-30)
The first continuous flow synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids directly from 2-aminopyridines and bromopyruvic acid has been developed, representing a significant advance over the corresponding in-flask method. The process was applied to the multistep synthesis of imidazo[1,2-a]pyridine-2-carboxamides, including a Mur ligase
P M Alliel et al.
European journal of biochemistry, 105(2), 343-351 (1980-04-01)
We have reported in a previous communication a kinetic study showing bromopyruvate to behave as an active-site-directed reagent for flavocytochrome b2. It is shown here that inactivation is accompanied by incorporation of 3 mol reagent/subunit of oxidized intact enzyme and
Alessio Bocedi et al.
Scientific reports, 8(1), 16050-16050 (2018-10-31)
Many proteins provided with disulfide bridges in the native state undergo amorphous irreversible aggregation when these bonds are not formed. Here we show that egg lysozyme displays a clever strategy to prevent this deleterious aggregation during the nascent phase when
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