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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

Sinonimo/i:

Dichloroacetic acid sodium salt

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About This Item

Formula condensata:
Cl2CHCO2Na
Numero CAS:
2156-56-1
Peso molecolare:
150.92
Numero CE:
218-461-3
Numero MDL:
MFCD00070489
Codice UNSPSC:
12352302
ID PubChem:
24861527
NACRES:
NA.22

Grado

for analytical purposes

Saggio

98%

Impurezze

<2% ethyl alcohol

Punto di fusione

198 °C (dec.) (lit.)

Gruppo funzionale

chloro

Stringa SMILE

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
LUPNKHXLFSSUGS-UHFFFAOYSA-M

Informazioni sul gene

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

Descrizione generale

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Applicazioni

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335,H351

Classi di pericolo

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
STBK2573
STBK0770
STBJ8996
STBJ4103
STBJ0423

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Sigma-Aldrich

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Hexokinase II Inhibitor II, 3-BP The Hexokinase II Inhibitor II, 3-BP, also referenced under CAS 1113-59-3, controls the biological activity of Hexokinase II. This small molecule/inhibitor is primarily used for Cell Structure applications.

Millipore

376817-M

Hexokinase II Inhibitor II, 3-BP

Methyl dichloroacetate &#8805;99%

Sigma-Aldrich

35840

Methyl dichloroacetate

Preparing microporous carbon from solid organic salt precursors using in situ templating and a fixed-bed reactor.
Atkinson JD & Rood MJ.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 160, 174-181 (2012)
Marie-Aline Neveu et al.
Oncotarget, 7(49), 81741-81749 (2017-01-14)
Reverting glycolytic metabolism is an attractive strategy for cancer therapy as upregulated glycolysis is a hallmark in various cancers. Dichloroacetate (DCA), long used to treat lactic acidosis in various pathologies, has emerged as a promising anti-cancer drug. By inhibiting the
Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate.
Pathak RK, et al.
ACS Chemical Biology, 9(5), 1178-1187 (2014)
Mario Ammendola et al.
Scientific reports, 10(1), 6521-6521 (2020-04-18)
The growing interest of oncologists in natural compounds such as polyphenols and flavonoids is encouraging the development of innovative and efficient carriers for the delivery of those drugs. This study examines carboxymethyl chitosan-based microcapsules created by spray drying as a
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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