162957
6-Hydroxydopamine hydrobromide
95% (HPLC), powder, neurotoxin
Sinonimo/i:
2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
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About This Item
Formula condensata:
(HO)3C6H2CH2CH2NH2 · HBr
Numero CAS:
Peso molecolare:
250.09
Beilstein:
3713280
Numero CE:
Numero MDL:
Codice UNSPSC:
12352116
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Nome del prodotto
6-Hydroxydopamine hydrobromide, 95%
Livello qualitativo
Saggio
95%
Stato
powder
Punto di fusione
216-220 °C (lit.)
Temperatura di conservazione
−20°C
Stringa SMILE
Br.NCCc1cc(O)c(O)cc1O
InChI
1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
MLACDGUOKDOLGC-UHFFFAOYSA-N
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Descrizione generale
Solutions should be freshly prepared and protected from exposure to light.
Applicazioni
6-Hydroxydopamine hydrobromide has been used:
- to induce Parkinson′s disease (PD) in mouse models to study the effects of tubastatin A (TBA) on nucleotide-binding oligomerization domain and leucine-rich repeat pyrin 3 domain (NLRP3) activation and cell injury in SH-SY5Y cells
- to induce pharmacological ablation of the sympathetic nerves to study the effect of hepatic sympathetic nerve activity (SNA) on hepatic steatosis during diet-induced obesity in mice
- to induce oxidative stress in mesencephalic cells to study its effect on p75NTR signaling in neuronal cells of the ventral mesencephalon
Azioni biochim/fisiol
6-Hydroxydopamine hydrobromide (6-OHDA) is a neurotoxin that elicits oxidative damage and destroys catecholaminergic or sympathetic terminals. It is commonly used to induce Parkinson′s disease in the experimental model. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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I clienti hanno visto anche
Woori Kim et al.
Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
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Toxicology, 304, 109-119 (2013-01-01)
6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to
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