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Merck
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Documenti

135828

Sigma-Aldrich

Benzamide

99%

Sinonimo/i:

Benzoic acid amide

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About This Item

Formula condensata:
C6H5CONH2
Numero CAS:
55-21-0
Peso molecolare:
121.14
Beilstein:
385876
Numero CE:
200-227-7
Numero MDL:
MFCD00007968
Codice UNSPSC:
12352100
ID PubChem:
24848219
NACRES:
NA.22

Saggio

99%

Punto di fusione

125-128 °C (lit.)

Solubilità

ethanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to light yellow

Stringa SMILE

NC(=O)c1ccccc1

InChI

1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
KXDAEFPNCMNJSK-UHFFFAOYSA-N

Informazioni sul gene

human ... PARP1(142)

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Descrizione generale

Benzamide on radioiodination by different labeling procedures results in large-scale production of radioiodinated benzamides having potential therapeutic application for patients with metastatic malignant melanoma.

Benzamide is used as a building block in organic synthesis for the preparation of various biologically active compounds.

Applicazioni

Benzamide was used to study the mechanism of photocatalytic decomposition of aqueous solution of acetic acid, acetamide and acetonitrile in the presence of semiconductors. It was used to develop a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

Azioni biochim/fisiol

Inhibits poly(ADP-ribose) polymerase (PARP).

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H341

Classi di pericolo

Acute Tox. 4 Oral - Muta. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

356.0 °F - closed cup

Punto d’infiammabilità (°C)

180 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Walter Mier et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(1), 9-14 (2013-11-28)
The performance of cytotoxic drugs is defined by their selectivity of uptake and action in tumor tissue. Recent clinical responses achieved by treating metastatic malignant melanoma with therapeutic modalities based on gene expression profiling showed that malignant melanoma is amenable
Photocatalytic Decompositions of Carboxylic Acid Derivatives by Semiconductors.
Park KH and Kim JH.
Bull. Korean Chem. Soc., 12(4), 439-439 (1991)
Willian G Birolli et al.
Pesticide biochemistry and physiology, 156, 129-137 (2019-04-28)
Chiral pesticides have been used in agriculture, including (±)-lambda-cyhalothrin ((±)-LC), which is a pyrethroid insecticide widely employed on crops for protection against different types of insects. However, enantioselectivity is poorly studied in biodegradation processes. Therefore, the (±)-LC enantioselective biodegradation by
Jamin D Steffen et al.
Journal of medicinal chemistry, 54(15), 5403-5413 (2011-06-23)
The metabolism of poly(ADP-ribose) (PAR) in response to DNA strand breaks, which involves the concerted activities of poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolase (PARG), modulates cell recovery or cell death depending upon the level of DNA damage. While PARP inhibitors
Anne Marie Hickey et al.
Biotechnology journal, 4(4), 510-516 (2009-03-18)
A (+)-gamma-lactamase was precipitated, cross-linked and the resulting solid crushed prior to immobilisation within a capillary column microreactor. The microreactor was subsequently used to study enzyme stability, activity, kinetics and substrate specificity. The thermophilic (+)-gamma-lactamase retained 100% of its initial
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