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Merck
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Key Documents

Altri documenti

118192

Sigma-Aldrich

Rhodanine

97%

Sinonimo/i:

2-Thioxo-4-thiazolidinone

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About This Item

Formula empirica (notazione di Hill):
C3H3NOS2
Numero CAS:
141-84-4
Peso molecolare:
133.19
Beilstein:
110701
Numero CE:
205-505-1
Numero MDL:
MFCD00005488
Codice UNSPSC:
12352100
ID PubChem:
24847363
NACRES:
NA.22

Livello qualitativo

100

Saggio

97%

Forma fisica

solid

Punto di fusione

165-169 °C (lit.)

Solubilità

methanol: soluble 2.5%, clear (yellow-green to orange-brown)

Stringa SMILE

O=C1CSC(=S)N1

InChI

1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
KIWUVOGUEXMXSV-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Rhodanine possess anticonvulsant, antibacterial, antiviral and antidiabetic activities.

Applicazioni

Rhodanine has been used in tannase assay in cultures of tannin degrading fungi.

Azioni biochim/fisiol

Rhodanine inhibits the multiplication of echovirus 12 and the development of virus-induced morphologic changes.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 - H319

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Sigma-Aldrich

Sigma-Aldrich

42395

Tannase from Aspergillus ficuum

Bispyrazolone for TLC derivatization, for the det.of cyanide, ≥98.0%

Supelco

15156

Bispyrazolone

Thiazolidine 95%

Sigma-Aldrich

149691

Thiazolidine

Neil S Cutshall et al.
Bioorganic & medicinal chemistry letters, 15(14), 3374-3379 (2005-06-18)
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this
Culture conditions for the production of a tannase of Aspergillus tamarii IMI388810 (B).
Enemuor SC and Odibo FJC.
African Journal of Biotechnology, 8(11), 2554-2557 (2009)
Matjaž Brvar et al.
Bioorganic & medicinal chemistry, 20(8), 2572-2580 (2012-03-27)
Bacterial DNA gyrase is an established and validated target for the development of novel antibacterials. In our previous work, we identified a novel series of bacterial gyrase inhibitors from the class of 4-(2,4-dihydroxyphenyl) thiazoles. Our ongoing effort was designated to
Parminder Singh et al.
Biochemistry, 51(27), 5434-5442 (2012-06-19)
A perturbation of FtsZ assembly dynamics has been shown to inhibit bacterial cytokinesis. In this study, the antibacterial activity of 151 rhodanine compounds was assayed using Bacillus subtilis cells. Of 151 compounds, eight strongly inhibited bacterial proliferation at 2 μM.
Ming-Xia Song et al.
European journal of medicinal chemistry, 54, 403-412 (2012-06-19)
Five series of (Z)-5-(4-(2-oxo-2-phenylethoxy)benzylidene)-2-thioxothiazolidin-4-one derivatives (I-V) were synthesized, characterized, and evaluated for their anti-bacterial activity. Most of the synthesized compounds showed potent inhibition against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with MIC values in the range of 1-32 μg/mL.
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