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10907

Sigma-Aldrich

Chloroacetaldehyde solution

produced by Wacker Chemie AG, Burghausen, Germany, ≥45.0% in H2O (density determination)

Sinonimo/i:

CLACH

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About This Item

Formula condensata:
ClCH2CHO
Numero CAS:
107-20-0
Peso molecolare:
78.50
Beilstein:
1071226
Numero CE:
203-472-8
Numero MDL:
MFCD00006992
Codice UNSPSC:
12352100
ID PubChem:
57646841
NACRES:
NA.22

Grado

produced by Wacker Chemie AG, Burghausen, Germany

Livello qualitativo

200

Stato

solid

Concentrazione

≥45.0% in H2O (density determination)

P. ebollizione

80-100 °C (lit.)

Gruppo funzionale

aldehyde
chloro

Stringa SMILE

[H]C(=O)CCl

InChI

1S/C2H3ClO/c3-1-2-4/h2H,1H2
QSKPIOLLBIHNAC-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

Chloroacetaldehyde is a reagent used for converting adenine and its nucleoseides into fluorescent etheno derivatives which can be analysed by HPLC. It was used for derivatization in fluorometric determination of arprinocid and analogous compounds in human plasma .

Azioni biochim/fisiol

Chloroacetaldehyde, a metabolite of ifosamide, influences oxidative phosphorylation in mitochondria. It causes breaking of DNA strands and strongly inhibits DNA synthesis.

Altre note

prices for bulk quantities on request

Avvertenze

Danger

Classi di pericolo

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

143.6 °F - closed cup

Punto d’infiammabilità (°C)

62 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificati d'analisi (COA)

Lot/Batch Number
BCCC9177
BCCD7290
BCCB0072
BCBQ6783V
BCBK7897V

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Preparation, titration, and storage of chloroacetaldehyde for fluorometric determination of adenine and its derivatives.
McCann WP, et al.
Analytical Chemistry, 55(8), 1454-1455 (1983)
Svenja K Brüggemann et al.
Cancer chemotherapy and pharmacology, 57(3), 349-356 (2005-09-01)
The ifosfamide metabolite chloroacetaldehyde had been made responsible for side effects only. We found in previous studies a strong cytotoxicity on human MX-1 tumor cells and xenografts in nude mice. Chloroacetaldehyde is supposed to act via alkylation or by inhibition
Fluorogenic reaction between adenine derivatives and chloroacetaldehyde and its application to the determination of 9-(2-chloro-6-fluorobenzyl) adenine in human plasma.
Matuszewski BK and Bayne WF.
Analytica Chimica Acta, 227, 189-202 (1989)
V Nagarajavel et al.
The Journal of biological chemistry, 282(32), 23622-23630 (2007-06-16)
H-NS inhibits transcription by forming repressing nucleoprotein complexes next to promoters. We investigated repression by binding of H-NS within the transcription unit using the bgl and proU operons. Repression of both operons requires a downstream regulatory element (DRE) in addition
Zeinab Yaseen et al.
Archives of toxicology, 82(9), 607-614 (2008-01-25)
The Fanconi syndrome is a common side effect of the chemotherapeutic agent ifosfamide. Current evidences suggest that chloroacetaldehyde (CAA), one of the main metabolites of ifosfamide activation, contributes to its nephrotoxicity. However, the pathophysiology of CAA-induced Fanconi syndrome is not
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