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Merck

SMAD4

SMAD family member 4

Sinonimi:
DPC4, JIP, MADH4, MYHRS
Specie:
ID UniProtKB:
ID gene:
  • Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
  • Mouse(17128) SMAD family member 4
  • Rat(50554) SMAD family member 4
  • Zebrafish(30640) MAD homolog 4 (Drosophila)
  • Horse(100033846) SMAD family member 4
  • domestic cat(101093650) SMAD family member 4
  • dog(476196) SMAD family member 4
  • naked mole-rat(101703764) SMAD family member 4
  • domestic guinea pig(100717853) SMAD family member 4
  • cow(540248) SMAD family member 4
  • sheep(443171) SMAD family member 4
  • Goat(100861019) SMAD family member 4

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ELISA

N° Catalogo
Descrizione
Specie
Human Smad4 ELISA, for serum, plasma and cell culture supernatants,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-SMAD4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse
Applicazione
immunofluorescence
immunohistochemistry

western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, clone 4G1C6, ascites fluid,
Reattività con
human
Applicazione
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-SMAD4 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM277, purified immunoglobulin,
Reattività con
human
Applicazione
immunohistochemistry
western blot
Anti-SMAD4 antibody produced in rabbit, affinity isolated antibody,
Reattività con
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat, sheep
Applicazione
immunohistochemistry
western blot
Monoclonal Anti-SMAD4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9774, purified immunoglobulin, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot

Cell Lines

N° Catalogo
Descrizione
Specie
A549 Cells GFP-SMAD4, ,
Specie
human
A549 Cells SMAD4 -/-, ,
Specie
human
SW48 Cells SMAD4 -/-, ,
Specie
human
DLD1 Cells SMAD4 -/-, ,
Specie
human

Proteins

N° Catalogo
Descrizione
Specie
SMAD4, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Smad4,
Specie
mouse
MISSION® esiRNA, targeting human SMAD4,
Specie
human