T2752

3,3′,5-Triiodo-L-thyronine sodium salt

≥95% (HPLC)

• Synonyme(s) : Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T₃
• Formule empirique (notation de Hill): C₁₅H₁₁I₃NNaO₄
• Numéro CAS: 55-06-1
• Poids moléculaire : 672.96
• Numéro Beilstein : 8179867
• Numéro CE : 200-223-5
• Numéro MDL: MFCD00002594
• Code UNSPSC : 51111800
• ID de substance PubChem : 24900071
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Pureté: ≥95% (HPLC)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Solubilité: ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to faintly yellow or pink
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
• Clé InChI: SBXXSUDPJJJJLC-YDALLXLXSA-M
• Informations sur le gène: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Description

Application

3,3′,5-Triiodo-L-thyronine sodium salt was used in Oligodendrocyte differentiation medium used for isolation and culture of rat and mouse oligodendrocyte precursor cells. The product was used as a test compound for incubating adipocyte cells, used for studying the impact of hormones and butyrate on modulation of porcine adipocyte beta-adrenergic receptors.

Actions biochimiques/physiologiques

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)−3,5−diiodo-L-tyrosine sodium salt or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine can enhance mood and neuropsychological function. The product also positively regulates the hepatic FGF21 expression and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation.

Notes préparatoires

3,3′,5-Triiodo-L-thyronine sodium salt dissolves in 1 M HCl:EtOH with a ratio of 1:4 at 10 mg/ml to yield a clear, colorless to yellow or faint pink solution.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)