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T0397

L-Thyroxine sodium salt pentahydrate

Name: <SC>L</SC>-Thyroxine sodium salt pentahydrate
Brand: SIGMA

γ-irradiated, powder, BioXtra, suitable for cell culture

Synonyme(s) :

3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄

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About This Item

Formule linéaire :

HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O

Numéro CAS:

6106-07-6

Poids moléculaire :

888.93

Numéro Beilstein :

5721845

Numéro CE :

200-221-4

Numéro MDL:

MFCD00149110

Code UNSPSC :

12352209

ID de substance PubChem :

24899887

Nomenclature NACRES :

NA.77

Source biologique

synthetic (organic)

Niveau de qualité

200

Stérilité

γ-irradiated

Gamme de produits

BioXtra

Pureté

≥98%

Forme

powder

Puissance

5-50 ng/mL

Technique(s)

cell culture | mammalian: suitable

Pf

207-210 (dec.) (lit.)

Solubilité

cell culture medium: 0.1 mg/mL
H₂O: soluble

Température de stockage

−20°C

Chaîne SMILES

O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1

Clé InChI

JMHCCAYJTTWMCX-QWPJCUCISA-M

Informations sur le gène

mouse ... Cnr2(12802)
rat ... Cnr1(25248)

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Catégories apparentées

Hormones

Actions biochimiques/physiologiques

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Forme physique

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution, add 50 ml sterile culture medium.

Pictogrammes

GHS08

Mention d'avertissement

Danger

Mentions de danger

H372

Conseils de prudence

P260 - P264 - P270 - P314 - P501

Classification des risques

STOT RE 1

Code de la classe de stockage

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Despite Cnidaria (sea anemones, corals, jellyfish, and hydroids) being the oldest venomous animal lineage, structure-function relationships, phyletic distributions, and the molecular evolutionary regimes of toxins encoded by these intriguing animals are poorly understood. Hence, we have comprehensively elucidated the phylogenetic

Less is more: extreme genome complexity reduction with ddRAD using Ion Torrent semiconductor technology.

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Molecular ecology resources, 15(5), 1145-1152 (2015-02-24)

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Essential gene discovery in the basidiomycete Cryptococcus neoformans for antifungal drug target prioritization.

Giuseppe Ianiri et al.

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Transcriptomic changes of Legionella pneumophila in water.

Laam Li et al.

BMC genomics, 16, 637-637 (2015-08-27)

Legionella pneumophila (Lp) is a water-borne opportunistic pathogen. In water, Lp can survive for an extended period of time until it encounters a permissive host. Therefore, identifying genes that are required for survival in water may help develop strategies to

Differential effects of the G118R, H51Y, and E138K resistance substitutions in different subtypes of HIV integrase.

Peter K Quashie et al.

Journal of virology, 89(6), 3163-3175 (2015-01-02)

Dolutegravir (DTG) is the latest antiretroviral (ARV) approved for the treatment of human immunodeficiency virus (HIV) infection. The G118R substitution, previously identified with MK-2048 and raltegravir, may represent the initial substitution in a dolutegravir resistance pathway. We have found that

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