SML1476

Thiocolchicoside

≥98% (HPLC)

• Synonyme(s) : (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Formule empirique (notation de Hill): C₂₇H₃₃NO₁₀S
• Numéro CAS: 602-41-5
• Poids moléculaire : 563.62
• Numéro CE : 210-017-7
• Numéro MDL: MFCD07995056
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825907
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -510 to -610°, c = 0.5 in H₂O
• Couleur: light yellow to dark yellow
• Solubilité: H₂O: 10 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• Clé InChI: LEQAKWQJCITZNK-AXHKHJLKSA-N

Description

Actions biochimiques/physiologiques

Thiocolchicoside acts as a muscle relaxant. In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol. Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301 - H341 - H361fd - H372
• Conseils de prudence: P201 - P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Organes cibles: Gastro-intestinal system
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable