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Key Documents

PHR1009

Supelco

Caféine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

1,3,7-triméthylxanthine

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About This Item

Formule empirique (notation de Hill):
C8H10N4O2
Numéro CAS:
Poids moléculaire :
194.19
Numéro Beilstein :
17705
Numéro MDL:
Code UNSPSC :
12352210
ID de substance PubChem :
Nomenclature NACRES :
NA.24

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

Agence

traceable to BP 766
traceable to Ph. Eur. C0100000
traceable to USP 1085003

Famille d'API

dimenhydrinate, caffeine, pentoxifylline

CofA (certificat d'analyse)

current certificate can be downloaded

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

234-236.5 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-30°C

Chaîne SMILES 

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

Clé InChI

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Informations sur le gène

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Description générale

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Caffeine is an N-methyl derivative of xanthine and is involved in gastric acid secretion, diuresis, and stimulation of the central nervous system.

Application

Caffeine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, blood plasma, food, drinks, and herbal products by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Autres remarques

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB7780 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Certificats d'analyse (COA)

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Les clients ont également consulté

Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.
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Journal of Chromatographic Science, 46(2), 144-149 (2008)
Simultaneous voltammetric determination of paracetamol and caffeine in pharmaceutical formulations using a boron-doped diamond electrode.
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Simultaneous determination of caffeine and non-steroidal anti-inflammatory drugs in pharmaceutical formulations and blood plasma by reversed-phase HPLC from linear gradient elution.
Mart?n MJ, et al.
Talanta, 49(2), 453-459 (1999)
Louise A Horrigan et al.
Pharmacology & therapeutics, 111(3), 877-892 (2006-03-17)
Caffeine is a member of the methylxanthine family of drugs, and is the most widely consumed behaviourally active substance in the western world. This article is focused on the impact of caffeine on immune function. In this regard, a number
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