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L0879

Sigma-Aldrich

Leu-Leu-Leu

≥90% (elemental analysis)

Synonyme(s) :

Trileucine

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About This Item

Formule empirique (notation de Hill):
C18H35N3O4
Numéro CAS:
10329-75-6
Poids moléculaire :
357.49
Numéro MDL:
MFCD00038309
Code UNSPSC :
12352200
ID de substance PubChem :
24896267
Nomenclature NACRES :
NA.26

Niveau de qualité

200

Pureté

≥90% (elemental analysis)

Forme

powder

Technique(s)

electron microscopy: suitable
mass spectrometry (MS): suitable

Couleur

white

Température de stockage

−20°C

Chaîne SMILES 

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

Clé InChI

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Catégories apparentées

Amino Acid Sequence

Leu-Leu-Leu

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Hui Ding et al.
Biomaterials, 34(1), 217-225 (2012-10-16)
Anionic polymers are valuable components used in cosmetics and health sciences, especially in drug delivery, because of their chemical versatility and low toxicity. However, because of their highly negative charge they pose problems for penetration through hydrophobic barriers such as
Hui Ding et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(42), 18143-18148 (2010-10-06)
Effective treatment of brain neurological disorders such as Alzheimer's disease, multiple sclerosis, or tumors should be possible with drug delivery through blood-brain barrier (BBB) or blood-brain tumor barrier (BTB) and targeting specific types of brain cells with drug release into
Anna Andrzejewska et al.
Journal of chromatography. A, 1216(18), 3992-4004 (2009-03-31)
The single-component equilibrium adsorption of the tripeptide Leucyl-Leucyl-Leucine (LLL) on a high-efficiency Jupiter Proteo column (C(12)) was investigated experimentally and modeled theoretically. The experimental equilibrium isotherms of LLL for adsorption on a C(12) packing material from an aqueous solution of
Rameshwar Patil et al.
Pharmaceutical research, 27(11), 2317-2329 (2010-04-14)
Temozolomide (TMZ) is a pro-drug releasing a DNA alkylating agent that is the most effective drug to treat glial tumors when combined with radiation. TMZ is toxic, and therapeutic dosages are limited by severe side effects. Targeted delivery is thus
Tsutomu Kabashima et al.
Peptides, 29(3), 356-363 (2008-01-09)
A novel and selective fluorescence reaction is proposed for the quantitative determination of peptides by reversed-phase liquid chromatography (RPLC). A single fluorescent product was formed when a peptide was heated at 120 degrees C for 20 min in a neutral
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