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Merck
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Key Documents

Autres documents

C2313

Sigma-Aldrich

Compound 48/80

powder,  hypotensive agent

Synonyme(s) :

Poly-p-methoxyphenethylmethylamine

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About This Item

Code UNSPSC :
41106300
Nomenclature NACRES :
NA.77

product name

Compound 48/80,

Forme

powder

Niveau de qualité

200

Solubilité

H2O: 50 mg/mL

Température de stockage

−20°C

Description générale

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

Application

Compound 48/80 has been used:
  • to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry
  • to induce mast cell degranulation
  • to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice

Actions biochimiques/physiologiques

Compound 48/80 (C 48/80) is a hypotensive agent, which promotes release of histamine. C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata. C 48/80 promotes degranulation of mast cells. It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca2+ ATPase and activates G proteins.

Notes préparatoires

Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301 + H311 + H331

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKC alpha
Byrne RD, et al.
Cellular Signalling, 19(2), 321-329 (2007)
Meng-Li Wu et al.
Signal transduction and targeted therapy, 6(1), 428-428 (2021-12-19)
SARS-CoV-2 infection-induced hyper-inflammation links to the acute lung injury and COVID-19 severity. Identifying the primary mediators that initiate the uncontrolled hypercytokinemia is essential for treatments. Mast cells (MCs) are strategically located at the mucosa and beneficially or detrimentally regulate immune
Y Koibuchi et al.
European journal of pharmacology, 115(2-3), 163-170 (1985-09-24)
Compound 48/80 and 14C-labeled compound 48/80 were synthesized, and fractionated by thin-layer chromatography into 14 components (A-N) with various histamine releasing activities and different Ca2+ requirements for their actions. The histamine release induced from rat mast cells in vitro by
Radhika Palkar et al.
The Journal of investigative dermatology, 138(6), 1391-1399 (2017-12-31)
Cooling or the application of mentholated liniments to the skin has been used to treat itch for centuries, yet remarkably little is known about how counter-stimuli such as these induce itch relief. Indeed, there is no clear consensus in the
Development of a short-term canine full-thickness skin organ culture method under serum-free conditions
Abramo F, et al.
American Journal of Animal and Veterinary Sciences, 11(2), 61-69 (2016)
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