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I6284

Sigma-Aldrich

Anti-Human IgE (ε-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonyme(s) :

Anti Human Ige, Anti-Human IgE - Anti-Human IgE (ε-chain specific) antibody produced in goat, Anti-Human Ige

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About This Item

Numéro MDL:
MFCD00162427
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

human

Technique(s)

Ouchterlony double diffusion: suitable

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

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Catégories apparentées

Description générale

IgE is a class of immunoglobulins that is produced only in mammals. IgE is secreted by mast cells in response to allergens and is important in immunity against parasites. It also is the most important factor in the pathophysiology of anaphylaxis or type I hypersensitivity. The antibody preparation is specific for human IgE when tested against purified human IgA, IgG, IgM, Bence Jones κ, and Bence Jones λ proteins. Identity and purity of the antibody is established by immunoelectrophoresis.

Immunogène

Purified human IgE (myeloma)

Application

Anti-Human IgE (epsilon-chain specific) antibody may be used as a control in various immunoassays.

Forme physique

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2.

Reconstitution

Reconstitute with 0.135 M sodium chloride to achieve a 1 mg/mL solution of antibody.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCF0672
SLBX4378
SLBN1928V
SLBL1084V
SLBJ0071V

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Consulter la Bibliothèque de documents

Shiteng Duan et al.
The Journal of clinical investigation, 129(3), 1387-1401 (2019-01-16)
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with
Bettina Wedi et al.
Allergy, 75(9), 2229-2242 (2020-02-01)
Mas-related G protein-coupled receptor X2 (MRGPRX2) is regarded as a mast cell-specific receptor mediating non-IgE-dependent activation. We aimed to investigate whether human basophils and eosinophils express functional MRGPRX2. Flow cytometry, immunocytochemistry, immunofluorescence, Western blot, and RT-PCR were performed in highly
Stephen J Galli et al.
Nature medicine, 18(5), 693-704 (2012-05-09)
Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence
Jie Zhao et al.
mAbs, 11(5), 837-847 (2019-04-06)
Asthma is characterized by airway hyperresponsiveness and inflammation, as well as underlying structural changes to the airways. Interleukin-4 (IL-4) is a key T-helper type 2 (Th2) cytokine that plays important roles in the pathogenesis of atopic and eosinophilic asthma. We
Minjae Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 208(3), 772-779 (2022-01-14)
Human IgE is useful for immunological assays, such as sensitization of FcεRI-positive cells and IgE measurement. In this study, we report the development of a recombinant Ig fragment, designated IgCw-γεκ, as an alternative reagent to human IgE. IgCw-γεκ (∼130 kDa)

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