A8381

L-asparagine monohydrate

≥99% (TLC)

• Synonyme(s) : 4-Amide d'acide (S)-2-aminosuccinamique, 4-Amide d'acide L-aspartique, Acide (S)-(+)-2-aminosuccinamique
• Formule linéaire : NH₂COCH₂CH(NH₂)COOH · H₂O
• Numéro CAS: 5794-13-8
• Poids moléculaire : 150.13
• Numéro Beilstein : 1723527
• Numéro CE : 200-735-9
• Numéro MDL: MFCD00151038
• Code UNSPSC : 12352209
• ID de substance PubChem : 24891338
• Nomenclature NACRES : NA.26

Propriétés

• product name: L-asparagine monohydrate, ≥99% (TLC)
• Source biologique: synthetic
• Pureté: ≥99% (TLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 233-235 °C (lit.)
• Application(s): cell analysis; peptide synthesis
• Chaîne SMILES: [H]O[H].N[C@@H](CC(N)=O)C(O)=O
• InChI: 1S/C4H8N2O3.H2O/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H2,6,7)(H,8,9);1H2/t2-;/m0./s1
• Clé InChI: RBMGJIZCEWRQES-DKWTVANSSA-N

Description

Description générale

Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds.

Application

L-Asparagine monohydrate has been used:

• as a component of Sauton′s and chelated Sauton′s media for mycobacterial growth
• to test its effect in the induction of Ca²⁺ flux in rice roots using aequorin luminescence imaging
• as a component of fermentation medium for the Blakeslea trispora spores

Actions biochimiques/physiologiques

Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods. Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.

L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)