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74667

Sigma-Aldrich

Nourseothricin sulfate

≥85% (HPLC)

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About This Item

Numéro CAS:
96736-11-7
Numéro MDL:
MFCD00165013
Code UNSPSC :
51102829
Nomenclature NACRES :
NA.85

Source biologique

Streptomyces noursei

Niveau de qualité

100

Pureté

≥85% (HPLC)

Forme

solid

Couleur

white to light brown

Solubilité

H2O: soluble 200 mg/mL

Adéquation

suitable for (selection agent for molecular genetic research work)

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria
fungi
mycobacteria
mycoplasma
parasites
viruses
yeast

Mode d’action

protein synthesis | interferes

Température de stockage

2-8°C

Description générale

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Actions biochimiques/physiologiques

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Conditionnement

10mg, 100mg

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Adrian J Verster et al.
G3 (Bethesda, Md.), 7(10), 3337-3347 (2017-08-26)
Genes encoding essential components of core cellular processes are typically highly conserved across eukaryotes. However, a small proportion of essential genes are highly taxonomically restricted; there appear to be no similar genes outside the genomes of highly related species. What
Dorota Fennessy et al.
PloS one, 9(5), e97683-e97683 (2014-05-23)
Targeted alteration of the genome lies at the heart of the exploitation of S. pombe as a model system. The rate of analysis is often determined by the efficiency with which a target locus can be manipulated. For most loci
Kristin L Patrick et al.
Cell systems, 7(3), 323-338 (2018-08-06)
Intracellular bacterial pathogens secrete a repertoire of effector proteins into host cells that are required to hijack cellular pathways and cause disease. Despite decades of research, the molecular functions of most bacterial effectors remain unclear. To address this gap, we
Tomokazu Murakawa et al.
Cell reports, 26(2), 338-345 (2019-01-10)
Degradation of mitochondria by selective autophagy, termed mitophagy, contributes to the control of mitochondrial quality. Bcl2-L-13 is a mammalian homolog of Atg32, which is an essential mitophagy receptor in yeast. However, the molecular machinery involved in Bcl2-L-13-mediated mitophagy remains to
Markus Mund et al.
Cell, 174(4), 884-896 (2018-07-31)
Clathrin-mediated endocytosis is an essential cellular function in all eukaryotes that is driven by a self-assembled macromolecular machine of over 50 different proteins in tens to hundreds of copies. How these proteins are organized to produce endocytic vesicles with high precision

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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