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69453

Sigma-Aldrich

L-Homocysteine

≥98.0% (NT)

Synonyme(s) :

(S)-2-Amino-4-mercaptobutyric acid

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About This Item

Formule linéaire :
HSCH2CH2CH(NH2)COOH
Numéro CAS:
6027-13-0
Poids moléculaire :
135.18
Numéro CE :
227-891-0
Numéro MDL:
MFCD00151320
Code UNSPSC :
12352204
ID de substance PubChem :
329761669
Nomenclature NACRES :
NA.32

product name

L-Homocysteine, ≥98.0% (NT)

Pureté

≥98.0% (NT)

Forme

powder

Activité optique

[α]/D 25.5±1.5°, c = 1 in 1 M HCl

Couleur

white

Pf

263-265 °C

Application(s)

cell analysis

Maladie(s) pertinente(s)

Alzheimer′s disease

Température de stockage

−20°C

Chaîne SMILES 

N[C@@H](CCS)C(O)=O

InChI

1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1

Clé InChI

FFFHZYDWPBMWHY-VKHMYHEASA-N

Description générale

L-homocysteine is used to diagnose homocystinuria.

Application

L-homocysteine has been used as a supplement in cell culture media.

Actions biochimiques/physiologiques

Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Assessment of homocysteine status
Refsum H, et al.
Journal of inherited metabolic disease, 20(2), 286-294 (1997)
Arpita Basu et al.
Atherosclerosis, 236(1), 188-195 (2014-07-27)
Plasma total homocysteine (tHcy) has been positively associated with carotid intima-media thickness (IMT) in non-diabetic populations and in a few cross-sectional studies of diabetic patients. We investigated cross-sectional and prospective associations of a single measure of tHcy with common and
Ioana Cotlarciuc et al.
Stroke, 45(7), 1920-1924 (2014-05-23)
Elevated total plasma homocysteine (tHcy) levels are known to be associated with increased risk of ischemic stroke (IS). Given that both tHcy and IS are heritable traits, we investigated a potential genetic relationship between homocysteine levels and stroke risk by
James J H Chong et al.
Journal of the American Heart Association, 8(1), e011028-e011028 (2019-01-01)
Background Neutrophil gelatinase-associated lipocalin ( NGAL ) or lipocalin 2 may promote atherosclerosis and plaque instability leading to increased risk of cardiac events. We investigated the relationships between plasma NGAL , cardiovascular disease biomarkers, and long-term cardiac events. Methods and
Rajendra P Shukla et al.
Advanced healthcare materials, 8(15), e1900462-e1900462 (2019-06-27)
The antipsychotic clozapine is the most effective medication available for schizophrenia and it is the only antipsychotic with a known efficacious clinical range. However, it is dramatically underutilized due to the inability to test clozapine blood levels in finger-pricked patients'
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