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44583

Sigma-Aldrich

Doxorubicine hydrochloride

suitable for fluorescence, 98.0-102.0% (HPLC)

Synonyme(s) :

DOX, Hydroxydaunorubicine hydrochloride

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About This Item

Formule empirique (notation de Hill) :
C27H29NO11 · HCl
Numéro CAS:
25316-40-9
Poids moléculaire :
579.98
Beilstein:
4229251
Numéro CE :
246-818-3
Numéro MDL:
MFCD00077757
Code UNSPSC :
51281818
ID de substance PubChem :
57650234
Nomenclature NACRES :
NA.76

Source biologique

synthetic

Essai

98.0-102.0% (HPLC)

Forme

solid

Couleur

orange to dark red

Pf

216 °C (dec.) (lit.)

Solubilité

H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble

Fluorescence

λem 580-590 nm

Adéquation

suitable for fluorescence

Spectre d'activité de l'antibiotique

neoplastics

Mode d’action

DNA synthesis | interferes
enzyme | inhibits

Température de stockage

2-8°C

Chaîne SMILES 

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

Clé InChI

MWWSFMDVAYGXBV-RUELKSSGSA-N

Informations sur le gène

human ... TOP2A(7153)

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Description générale

Chemical structure: tetracycline

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Actions biochimiques/physiologiques

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H340,H350,H360FD

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
WXBD1159V
0000036131
079M4767V
079M4766V
079M4765V

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