74601

3,3′-Diindolylmethane

analytical standard

• Synonyme(s) : DIM
• Formule empirique (notation de Hill): C₁₇H₁₄N₂
• Numéro CAS: 1968-05-4
• Poids moléculaire : 246.31
• Numéro MDL: MFCD00195766
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Niveau de qualité: 100
• Pureté: ≥97.5% (HPLC)
• Durée de conservation: limited shelf life, expiry date on the label
• Application(s): food and beverages
• Format: neat
• Température de stockage: 2-8°C
• Chaîne SMILES: C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34
• InChI: 1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
• Clé InChI: VFTRKSBEFQDZKX-UHFFFAOYSA-N

Description

Description générale

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Application

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Actions biochimiques/physiologiques

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G₁ cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H⁺-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

Produits recommandés

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335,H413
• Conseils de prudence: P273 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable