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08010

Supelco

Safrole

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonyme(s) :

4-Allyl-1,2-methylenedioxybenzene, 5-Allyl-1,3-benzodioxole

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About This Item

Formule empirique (notation de Hill):
C10H10O2
Numéro CAS:
94-59-7
Poids moléculaire :
162.19
Numéro Beilstein :
136380
Numéro CE :
202-345-4
Numéro MDL:
MFCD00005841
Code UNSPSC :
41116107
ID de substance PubChem :
329748537
Nomenclature NACRES :
NA.24

Qualité

certified reference material
TraceCERT®

Niveau de qualité

300

Pression de vapeur

1 mmHg ( 63.8 °C)

Gamme de produits

TraceCERT®

Fabricant/nom de marque

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Technique(s)

gas chromatography (GC): suitable

Indice de réfraction

n20/D 1.537 (lit.)

Point d'ébullition

232-234 °C (lit.)

Pf

11.2 °C (lit.)

Densité

1.095 g/mL at 25 °C (lit.)

Application(s)

cleaning products
cosmetics
food and beverages
personal care

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

C=CCc1ccc2OCOc2c1

InChI

1S/C10H10O2/c1-2-3-8-4-5-9-10(6-8)12-7-11-9/h2,4-6H,1,3,7H2

Clé InChI

ZMQAAUBTXCXRIC-UHFFFAOYSA-N

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Description générale

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Actions biochimiques/physiologiques

Safrole is a naturally-occurring genotoxic compound found in Sassafras root and Areca (betel) quid. It is a hepatocarcinogen, and safrole-DNA adducts have also been seen in oral cancers of Areca users. Metabolites of safrole form adducts with DNA and induce chromasomal aberrations and sister chromatid exchanges.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Autres remarques

Principal constituent of sassafras oil

Informations légales

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H315,H341,H350

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Irrit. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

212.0 °F - closed cup

Point d'éclair (°C)

100 °C - closed cup

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Certificats d'analyse (COA)

Lot/Batch Number
BCCG7808
BCCG1919
BCBV9943
BCBM6926V
BCBH8303V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Chia-Jung Lee et al.
Molecules (Basel, Switzerland), 25(19) (2020-10-11)
Acne is a common skin condition observed in adolescents. Nutmeg (Myristica fragrans Houtt) (MF) is a well-known traditional Chinese medicine; its major toxic components, safrole and myristicin, are rich in essential oils. Essential oils of MF (MFO) were extracted by
Chun-Shu Yu et al.
Anticancer research, 32(5), 1671-1679 (2012-05-18)
Safrole, a component of Piper betle inflorescence, is a carcinogen which has been demonstrated to induce apoptosis on human oral cancer HSC-3 cells in vitro and to inhibit HSC-3 cells in xenograft tumor cells in vivo. In our previous study
Héctor Carrasco et al.
Molecules (Basel, Switzerland), 17(1), 1002-1024 (2012-01-21)
Twenty one phenylpropanoids (including eugenol and safrole) and synthetic analogues, thirteen of them new compounds, were evaluated for antifungal properties, first with non-targeted assays against a panel of human opportunistic pathogenic fungi. Some structure-activity relationships could be observed, mainly related
Li-Ching Shen et al.
Toxicology letters, 213(3), 309-315 (2012-07-24)
Safrole, a naturally occurring product derived from spices and herbs, has been shown to be associated with the development of hepatocellular carcinoma in rodents. Safrole 2',3'-oxide (SFO), an electrophilic metabolite of safrole, was shown to react with DNA bases to
Le Su et al.
Toxicology letters, 217(2), 129-136 (2012-12-29)
Safrole-2',3'-oxide (SFO) is the major electrophilic metabolite of safrole (4-allyl-1, 2-methylenedioxybenzene), a natural plant constituent found in essential oils of numerous edible herbs and spices and in food containing these herbs, such as pesto sauce, cola beverages and bologna sausages.
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