523310

Pterostilbene, Pterocarpus marsupium

A cell-permeable methoxylated analog of Resveratrol that displays antioxidant, antiproliferative, and hypoglycemic properties.

• Synonyme(s) : Pterostilbene, Pterocarpus marsupium, trans-3,5-Dimethoxy-4ʹ-hydroxystilbene
• Formule empirique (notation de Hill): C₁₆H₁₆O₃
• Numéro CAS: 537-42-8
• Poids moléculaire : 256.30
• Numéro MDL: MFCD00238710
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 10 mg/mL; methanol: 10 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+
• Clé InChI: VLEUZFDZJKSGMX-ONEGZZNKSA-N

Description

Description générale

A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, antiproliferative, and hypoglycemic properties. Moderately inhibits COX-1 and -2 activities (IC₅₀ = 19.8 µM and 83.9 µM) respectively, induces apoptosis in HL60 cells (IC₅₀ = 70 µM), prevents DMBA-induced preneoplastic lesions (ED₅₀ = 4.8 µM) and decreases plasma glucose level in streptozotocin-induced diabetic rats comparable to that of Metformin.

A cell-permeable methoxylated analog of Resveratrol (Cat. No. 554325) that displays antioxidant, anti-proliferative, and hypoglycemic properties. Appears to be a better free radical scavenger than Trolox (Cat. No. 64847). Moderately inhibits COX-1 & COX-2 activities (IC₅₀ = 19.8 µM & 83.9 µM, respectively) and induces apoptosis in HL60 cells (IC₅₀ = 70 µM). Also prevents DMBA-induced pre-neoplastic lesions (ED₅₀ = 4.8 µM). Reported to decrease plasma glucose levels in streptozotocin-induced diabetic rats comparable to that of Metformin.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
COX-1 and COX-2 activities

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 19.8 µM, 83.9 µM against COX-1 and -2 activities, respectively; 70 µM for inducing apoptosis in HL60 cells; ED50 = 4.8 µM for preventing DMBA-induced preneoplastic lesions

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Roberti, M., et al. 2003. J. Med. Chem.46, 3546.
Rimando, A.M., et al. 2002. J. Agric. Food Chem.50, 3453.
Manickam, M., et al. 1997. J. Nat. Prod.60, 609.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H318,H411
• Conseils de prudence: P273 - P280 - P305 + P351 + P338 - P391 - P501
• Classification des risques: Aquatic Chronic 2 - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable