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Merck
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Key Documents

12-439

Sigma-Aldrich

Retinoblastoma Protein (aa 773-928)

Recombinant fusion protein containing the C-terminal fragment (residues 773-928) of human retinoblastoma protein (Rb) with an N-terminal His6-tag, expressed in E. coli.

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About This Item

Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.41

Produit recombinant

expressed in E. coli

Niveau de qualité

100

Forme

liquid

Fabricant/nom de marque

Upstate®

Concentration

2.0 mg/mL

Technique(s)

activity assay: suitable (kinase)

Numéro d'accès NCBI

NM_000321.2

Numéro d'accès UniProt

P06400

Conditions d'expédition

dry ice

Informations sur le gène

human ... RB1(5925)

Qualité

Routinely evaluated as a sustrate for many Serine/Threonine kinases.

Forme physique

50 mM Tris-HCl, pH 7.5, 150 mM NaCl, and 500 mM imidazole

Stockage et stabilité

Stable for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

CorrosionHealth hazard
GHS05,GHS08

Mention d'avertissement

Danger

Mentions de danger

H314 - H360D

Classification des risques

Eye Dam. 1 - Repr. 1B - Skin Corr. 1C

Code de la classe de stockage

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Alberto Viera et al.
Journal of cell science, 128(1), 88-99 (2014-11-09)
In most organisms, telomeres attach to the nuclear envelope at the onset of meiosis to promote the crucial processes of pairing, recombination and synapsis during prophase I. This attachment of meiotic telomeres is mediated by the specific distribution of several
Huikun Zhang et al.
PLoS computational biology, 15(8), e1006813-e1006813 (2019-08-06)
Prediction of compounds that are active against a desired biological target is a common step in drug discovery efforts. Virtual screening methods seek some active-enriched fraction of a library for experimental testing. Where data are too scarce to train supervised
Severine Isabelle Gharbi et al.
NPJ breast cancer, 8(1), 126-126 (2022-11-30)
Despite the biological and therapeutic relevance of CDK4/6 for the treatment of HR+, HER2- advanced breast cancer, the detailed mode of action of CDK4/6 inhibitors is not completely understood. Of particular interest, phosphorylation of CDK4 at T172 (pT172) is critical
Michael J O'Connor et al.
Oncogene, 40(30), 4872-4883 (2021-06-24)
Cyclin D1 is an essential regulator of the G1-S cell-cycle transition and is overexpressed in many cancers. Expression of cyclin D1 is under tight cellular regulation that is controlled by many signaling pathways. Here we report that PARP14, a member
Xueqian Gong et al.
Cancer cell, 32(6), 761-776 (2017-12-13)
Most cancers preserve functional retinoblastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CDK6. To date, CDK4/6 inhibitors have shown promising clinical activity in breast cancer and lymphomas, but it is not clear which additional

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