810250C

25-NBD Cholesterol

Avanti Polar Lipids 810250C

• Synonyme(s) : 25-[N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)methyl]amino]-27-norcholesterol
• Formule empirique (notation de Hill): C₃₃H₄₈N₄O₄
• Numéro CAS: 105539-27-3
• Poids moléculaire : 564.76
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Essai: >99% (TLC)
• Forme: liquid
• Conditionnement: pkg of 1 × 1 mL (810250C-10mg); pkg of 1 × 1 mL (810250C-1mg); pkg of 1 × 1 mL (810250C-5mg)
• Fabricant/nom de marque: Avanti Polar Lipids 810250C
• Concentration: 1 mg/mL (810250C-1mg); 10 mg/mL (810250C-10mg); 5 mg/mL (810250C-5mg)
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C33H48N4O4/c1-20(7-6-8-21(2)36(5)28-13-14-29(37(39)40)31-30(28)34-41-35-31)25-11-12-26-24-10-9-22-19-23(38)15-17-32(22,3)27(24)16-18-33(25,26)4/h9,13-14,20-21,23-27,38H,6-8,10-12,15-19H2,1-5H3/t20-,21?,23+,24+,25+,26+,27+,32+,33-/m1/s1
• Clé InChI: RMGLSQAGXRZCPZ-OVHOIDCTSA-N

Description

Description générale

25-NBD Cholesterol is a fluorescent derivative of cholesterol. Its fluorescent property is due to presence of NBD (2-(4-nitro-2,1,3-benzoxadiazol-7-yl) aminoethyl) group.

Application

25-NBD Cholesterol can be used as a labeling agent for confocal microscopy in studying endosomal trafficking and vesicle formation.

Actions biochimiques/physiologiques

Cholesterol is synthesized via a cascade of enzymatic reactions known as the mevalonate pathway. Cholesterol plays a major role in the architecture and stability of the plasma membrane and is also involved in the synthesis of cholecalciferol (Vitamin D3). Cholesterol build up on the walls or arteries causes obstruction of blood flow leading to a serious condition called artherosclerosis. It is a precursor for bile acid and for the synthesis of steroid hormones like progesterone, testosterone, cortisol, and aldosterone.

Conditionnement

5 mL Clear Glass Sealed Ampule (810250C-10mg)

5 mL Clear Glass Sealed Ampule (810250C-1mg)

5 mL Clear Glass Sealed Ampule (810250C-5mg)

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H302 - H315 - H319 - H331 - H336 - H351 - H361d - H372
• Conseils de prudence: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Classification des risques: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): does not flash
• Point d'éclair (°C): does not flash