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V4512

Sigma-Aldrich

Vascular Endothelial Growth Factor from mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym(e):

mVEGF, VEGF

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About This Item

MDL-Nummer:
MFCD01636149
UNSPSC-Code:
12352202
NACRES:
NA.77

Produktbezeichnung

Vascular Endothelial Growth Factor from mouse, VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Biologische Quelle

mouse

Qualitätsniveau

100

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

Form

powder

Wirksamkeit

≤10 ng/mL

Qualität

endotoxin tested

Mol-Gew.

protein 39 kDa

Verpackung

pkg of 10 μg
pkg of 50 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

<1 EU/μg

UniProt-Hinterlegungsnummer

Q00731

Lagertemp.

−20°C

Angaben zum Gen

mouse ... VEGFA(22339)

Allgemeine Beschreibung

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.

Anwendung

Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).

Sonstige Hinweise

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.
2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Physikalische Form

Lyophilized from a 0.2 μm filtered buffered solution.

Hinweis zur Analyse

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCQ7358
MKCP4955
MKCN4604
MKCN2326
MKCM3353

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J Sundaram et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 690-700 (2014-07-01)
Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. To investigate
Katsuhisa Tashiro et al.
Stem cells and development, 23(18), 2202-2210 (2013-12-19)
Vascular endothelial growth factor (VEGF) is reported to exhibit potent hematopoietic stem/progenitor cell (HSPC) mobilization activity. However, the detailed mechanisms of HSPC mobilization by VEGF have not been examined. In this study, we investigated the effect of VEGF on bone
Asieh Golozar et al.
European journal of cancer (Oxford, England : 1990), 50(16), 2855-2865 (2014-08-31)
Mechanisms involved in wound healing play some role in carcinogenesis in multiple organs, likely by creating a chronic inflammatory milieu. This study sought to assess the role of genetic markers in selected inflammation-related genes involved in wound healing (interleukin (IL)-1a
Benjamin B Bartelle et al.
Circulation research, 110(7), 938-947 (2012-03-01)
The formation and maintenance of a functional vasculature is essential for normal embryonic development, and genetic changes that affect the vasculature underlie pathogenesis in many human diseases. In vivo imaging in mouse models is required to understand the full complexity
Jafar Rezaie et al.
Journal of cellular biochemistry, 119(1), 524-535 (2017-06-14)
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level of Ang-1, Ang-2, cell migration, and trans-differentiation into pericytes and endothelial
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Artikel

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGF-A (VEGF) is a potent growth factor for blood vessel endothelial cells, showing pleiotropic responses that facilitate cell migration, proliferation, tube formation, and survival. In the developing embryo VEGF-A mRNA is expressed by cells within tissues undergoing capillarization.

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