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V105

Sigma-Aldrich

S(−)-Verapamil hydrochloride hydrate

≥98% (HPLC), powder

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About This Item

Empirische Formel (Hill-System):
C27H38N2O4 · HCl · xH2O
CAS-Nummer:
36622-28-3
Molekulargewicht:
491.06 (anhydrous basis)
EG-Nummer:
253-132-8
MDL-Nummer:
MFCD11045898
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24900705
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Optische Aktivität

[α]22/D −6.1°, c = 0.1 in ethanol(lit.)

Lagerbedingungen

desiccated
protect from light

Farbe

white to beige

Löslichkeit

H2O: >30 mg/mL
ethanol: soluble

SMILES String

O.Cl.COc1ccc(CCN(C)CCC[C@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m0../s1

InChIKey

ICKXRKHJKXMFLR-LPCSYZHESA-N

Biochem./physiol. Wirkung

Active enantiomer of (±)-verapamil. Ca2+ channel (L-type) modulator; adrenoceptor antagonist; cardiac depressant.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Samuel M Meier-Menches et al.
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Yanyu Zhao et al.
Cell, 177(6), 1495-1506 (2019-06-01)
The L-type voltage-gated Ca2+ (Cav) channels are modulated by various compounds exemplified by 1,4-dihydropyridines (DHP), benzothiazepines (BTZ), and phenylalkylamines (PAA), many of which have been used for characterizing channel properties and for treatment of hypertension and other disorders. Here, we
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Stem cell research & therapy, 10(1), 144-144 (2019-05-23)
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Alice C Wyse-Jackson et al.
The European journal of neuroscience, 44(12), 3067-3079 (2016-10-21)
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