P1793

Pimozid

≥98% (TLC), powder, D₂ dopamine receptor antagonist

• Synonym(e): 1-[1-[4,4-Bis(4-fluorphenyl)-butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-on
• Empirische Formel (Hill-System): C₂₈H₂₉F₂N₃O
• CAS-Nummer: 2062-78-4
• Molekulargewicht: 461.55
• EG-Nummer: 218-171-7
• MDL-Nummer: MFCD00055081
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277923
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Pimozid,
• Form: powder
• Löslichkeit: DMSO: 18 mg/mL(lit.); chloroform: 5 mg/mL; H₂O: insoluble(lit.)
• Ersteller: Teva
• Lagertemp.: 2-8°C
• SMILES String: Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
• InChI: 1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
• InChIKey: YVUQSNJEYSNKRX-UHFFFAOYSA-N
• Angaben zum Gen: human ... ABCB1(5243) , CACNA1G(8913) , CYP3A4(1576) , DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , HTR2A(3356) , HTR7(3363) , KCNH1(3756) , KCNH2(3757) , OPRD1(4985) ; mouse ... Abcb1a(18671) , Abcb1b(18669) ; rat ... Scnn1g(24768)

Beschreibung

Biochem./physiol. Wirkung

D₂ dopamine receptor antagonist; binds with high affinity to the cloned 5-HT₇ receptor; Ca²⁺ channel antagonist; antipsychotic

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable