T123

Thioperamide maleate salt

solid

• Synonym(e): MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt
• Empirische Formel (Hill-System): C₁₅H₂₄N₄S · C₄H₄O₄
• CAS-Nummer: 148440-81-7
• Molekulargewicht: 408.52
• MDL-Nummer: MFCD00083209
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277809
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated; under inert gas
• Farbe: white
• Löslichkeit: H₂O: >10 mg/mL; DMSO: 12 mg/mL; ethanol: 3 mg/mL
• SMILES String: OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3
• InChI: 1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChIKey: REZRBLGMJZZSID-BTJKTKAUSA-N
• Angaben zum Gen: human ... HRH3(11255)

Beschreibung

Anwendung

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem./physiol. Wirkung

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves