C6492

Ciproxifan hydrochloride

≥98% (HPLC), solid

• Synonym(e): Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride
• Empirische Formel (Hill-System): C₁₆H₁₈N₂O₂ · HCl
• CAS-Nummer: 1049741-81-2
• Molekulargewicht: 306.79
• MDL-Nummer: MFCD08705321
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724449
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: desiccated; under inert gas
• Farbe: off-white
• Löslichkeit: DMSO: 30 mg/mL; water, high purity: 30 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
• InChI: 1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
• InChIKey: PWAPSKMHZQQTRJ-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Ciproxifan belongs to a novel chemical series of histamine H₃-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H₃ autoreceptor controlling ³H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H₃ receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H₃ receptor labeled with ¹²⁵I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H₃-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves