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Merck

SRP3318

Sigma-Aldrich

C1 Inhibitor Peptide

≥95% (HPLC), lyophilized powder, human recombinant, expressed in CHO cells

Synonym(e):

C1inh, Plasma protease C1 inhibitor, Serpin G1

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

product name

C1 Inhibitor human, recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)

Biologische Quelle

human

Rekombinant

expressed in CHO cells

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

Form

lyophilized

Wirksamkeit

≤2.6 nM IC50

Mol-Gew.

52.8 kDa

Verpackung

pkg of 200 μg

Verunreinigungen

endotoxin, tested

UniProt-Hinterlegungsnummer

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... SERPING1(710)

Allgemeine Beschreibung

Plasma protease C1 inhibitor is a member of the serpin family of structurally related proteins. Recombinant Human C1 inhibitor is a highly glycosylated glycoprotein containing 478 amino acid residues (52.8kDa), corresponding to amino acids 23-500 of the C1 inhibitor precursor, and is fully functional in its ability to inhibit the C1 complex. Glycosylated C1 inhibitor migrates at an apparent molecular weight of approximately 80-90kDa by SDS PAGE analysis under reducing conditions.

Biochem./physiol. Wirkung

Plasma protease C1 inhibitor is the primary regulator of the immune complement system. C1 inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1 inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1 inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1 inhibitor can be used to treat HAE and certain other conditions.

Physikalische Form

Lyophilized from 10mM Sodium Phosphate, pH 7.5.

Rekonstituierung

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

C1 inhibitor.
A E Davis et al.
Methods in enzymology, 223, 97-120 (1993-01-01)
C1-inhibitor deficiency and angioedema.
Carugati A
Molecular Immunology, 38(2-3), 161-173 (2001)
C1 Esterase Inhibitor (Human)
P & T : A Peer-Reviewed Journal for Formulary Management, 35, 2-3 (2010)
Sayani Mukherjee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(41), 7965-7979 (2020-09-06)
Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-activated neuronal death of the stress regulatory proopiomelanocortin (POMC) neuron-producing β-endorphin peptides in the hypothalamus in a postnatal rat model of fetal alcohol spectrum disorders. We determined
In vivo biosynthesis of endogenous and of human C1 inhibitor in transgenic mice: tissue distribution and colocalization of their expression.
Vinci G
Journal of Immunology, 169(10), 5948-5954 (2002)

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