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A6150

Sigma-Aldrich

α1-Antitrypsin aus Humanplasma

salt-free, lyophilized powder

Synonym(e):

α1-Proteinase-Inhibitor

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About This Item

CAS-Nummer:
9041-92-3
EG-Nummer:
232-924-7
MDL-Nummer:
MFCD00130469
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human plasma

Qualitätsniveau

200

Form

salt-free, lyophilized powder

Konzentration

≥60% (biuret)

Methode(n)

inhibition assay: suitable

UniProt-Hinterlegungsnummer

P01009
P08246

Lagertemp.

2-8°C

Angaben zum Gen

human ... ELA2(1991) , ELANE(1991) , SERPINA1(5265)

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Biochem./physiol. Wirkung

≤10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. ≤10 mg will inhibit approx. 1.0 mg of ·α-chymotrypsin with activity of 40-50 BTEE units per mg protein.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.
Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α1-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α1-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

Vorsicht

Wässrige Stammlösungen mit 0.01% NaN3 sind mehrere Monate lang stabil Die Lösungen können bei -80°C aufbewahrt werden, sollten aber nach dem Auftauen nicht wieder eingefroren werden. Instabil unterhalb pH 5.5. Wird inaktiviert durch einige non-serine Proteasen und durch Oxidation der Methionin Seitenkette des aktiven Zentrums.

Angaben zur Herstellung

Chromatographically prepared and partially purified.

Haftungsausschluss

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000276537
0000276485
0000276748
0000276485
0000276748

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Tian-Hui Yang et al.
Journal of immunology (Baltimore, Md. : 1950), 201(5), 1389-1399 (2018-07-20)
Proteinase 3 (P3), a serine protease expressed by myeloid cells, localized within azurophil granules, and also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN), is the target of autoimmunity in granulomatosis with polyangiitis. PR1, an HLA-A2 restricted nonameric peptide
Cynthia L Bristow et al.
Journal of immunology (Baltimore, Md. : 1950), 180(1), 492-499 (2007-12-22)
To identify positive or negative factors for HIV-1 infectivity, clones from the U937 promonocytic cell line that express similar levels of CD4 and CXCR4, but differ in HIV-1 susceptibility, were compared. In contrast to HIV-1 permissive clone 10 (plus), nonpermissive
Kathirvel Alagesan et al.
Analytical and bioanalytical chemistry, 409(2), 529-538 (2016-12-03)
Glycopeptide enrichment is a crucial step in glycoproteomics for which hydrophilic interaction chromatography (HILIC) has extensively been applied due to its low bias towards different glycan types. A systematic evaluation of applicable HILIC mobile phases on glycopeptide enrichment efficiency and
Ekaterina Mindel et al.
Journal of neuroscience research, 99(3), 966-976 (2020-12-10)
Many coagulation factor proteases are increased in the brain during ischemic stroke. One of these proteases is plasmin. In this study we established a novel method for direct quantitative measurement of plasmin activity in male mouse brain slices using a
C M de Bont et al.
Clinical and experimental immunology, 199(1), 1-8 (2019-10-30)
Neutrophils can form neutrophil extracellular traps (NETs) to capture microbes and facilitate their clearance. NETs consist of decondensed chromatin decorated with anti-microbial proteins. Here, we describe the effect of neutrophil proteases on the protein content of NETs. We show that

Artikel

Elastase

Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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