SML2920

Y-39983 dihydrochloride

≥98% (HPLC)

• Synonym(e): 4-[(1R)-1-Aminoethyl]-N-1H-pyrrolo[2,3-b]pyridin-4-yl-benzamide dihydrochloride, Y 39983, Y39983
• Empirische Formel (Hill-System): C₁₆H₁₆N₄O · 2HCl
• CAS-Nummer: 173897-44-4
• Molekulargewicht: 353.25
• MDL-Nummer: MFCD00945328
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +5 to +9°, c = 1 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: N[C@@H](C1=CC=C(C(NC2=CC=NC3=C2C=CN3)=O)C=C1)C.Cl.Cl
• InChI: 1S/C16H16N4O.2ClH/c1-10(17)11-2-4-12(5-3-11)16(21)20-14-7-9-19-15-13(14)6-8-18-15;;/h2-10H,17H2,1H3,(H2,18,19,20,21);2*1H/t10-;;/m1../s1
• InChIKey: CKFHAVRPVZNMGT-YQFADDPSSA-N

Beschreibung

Biochem./physiol. Wirkung

Y-39983 is a potent and selective Rho-kinase (ROCK) inhibitor (IC₅₀s = 3.6 nM). Y-39983 is 10 fold more potent in promoting the outgrowth of neurites in cultured retinal slices and axonal regeneration in crushed optic nerve models than Y-27632. Y-39983 act also as an activator of the neuroprotective Parkin-mediated mitophagy pathway.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable