SML2282

Everolimus

≥95% (HPLC), powder, P-glycoprotein substrate

• Synonym(e): Everolimus, 42-O-(2-Hydroxyethyl)-rapamycin
• Empirische Formel (Hill-System): C₅₃H₈₃NO₁₄
• CAS-Nummer: 159351-69-6
• Molekulargewicht: 958.22
• MDL-Nummer: MFCD00929329
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Everolimus, ≥95% (HPLC)
• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: O=C(C([C@@]1(O)[C@H](C)CC[C@](C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C2=O)([H])O1)=O)N3[C@H](C(O[C@@]([C@@H](C[C@@]4([H])C[C@@H](OC)[C@H](OCCO)CC4)C)([H])CC([C@H](C)/C=C(C)/[C@@H](O)[C@H]2OC)=O)=O)CCCC3
• InChI: 1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
• InChIKey: HKVAMNSJSFKALM-GKUWKFKPSA-N
• Angaben zum Gen: human ... FKBP1A(2280)

Beschreibung

Anwendung

Everolimus has been used as an mechanistic target of rapamycin complex 1 (mTORC1) inhibitor to study its effect on MCF7 and MDA-MB-231 cell lines.

Biochem./physiol. Wirkung

Everolimus, a substrate for P-glycoprotein (P-gp) can be used to treat advanced neuroendocrine tumors (NETs).

Everolimus, the 40-O-(2-hydroxyethyl) derivative of rapamycin (sirolimus), is a potent and selective inhibitor of mechanistic target of rapamycin (mTOR). Everolimus is selective for the mTORC1 protein complex. Everolimus exhibit potent immunosuppressive and anticancer activities.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H351,H361fd,H373,H410
• P-Sätze: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Gefahreneinstufungen: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 2 - STOT RE 2
• Zielorgane: Kidney,Testes
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable