SML1464

SMBA1

≥98% (HPLC)

• Synonym(e): 2-[(2-Nitro-9H-fluoren-9-ylidene)methyl]-phenol, 2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
• Empirische Formel (Hill-System): C₂₀H₁₃NO₃
• CAS-Nummer: 906440-37-7
• Molekulargewicht: 315.32
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825898
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: OC(C=CC=C1)=C1/C=C2C(C=CC=C3)=C3C4=C\2C=C([N+]([O-])=O)C=C4
• InChI: 1S/C20H13NO3/c22-20-8-4-1-5-13(20)11-18-16-7-3-2-6-15(16)17-10-9-14(21(23)24)12-19(17)18/h1-12,22H/b18-11+
• InChIKey: PEYKRJBXACUOOB-WOJGMQOQSA-N

Beschreibung

Biochem./physiol. Wirkung

SMBA1 is a potent and selective Bax agonist.

SMBA1 is an anti-tumor agent. It exhibits anti-proliferative effects against glioblastoma (GBM) cells.

Small-molecule Bax agonists 1 (SMBA1) is a potent and selective Bax agonist that binds to Bax, induces conformational change which blocks Bax S184 phosphorylation. SMBA1 induces apoptosis in cancer cells and suppresses lung tumor growth in vivo without significant normal tissue toxicity. SMBA1 does not bind to other B-cell lymphoma 2 (Bcl-2) family members.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable