SML1174

ML120B

≥98% (HPLC)

• Synonym(e): MLN120B, N-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide
• Empirische Formel (Hill-System): C₁₉H₁₅ClN₄O₂
• CAS-Nummer: 783348-36-7
• Molekulargewicht: 366.80
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: Clc1cc2c([nH]c4c2ccnc4)c(c1OC)NC(=O)c3c(nccc3)C
• InChI: 1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25)
• InChIKey: ZNOLRTPMNMPLHY-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ML120B is a potent inhibitor of IKK-2 (IC₅₀ = 60 nM). ML120B is orally bioavailable, and inhibits paw swelling, bone and cartilage degradation, and weight loss in rat adjuvant-induced arthritis.

ML120B is a potent inhibitor of IKK-2.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable